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In many states, the legal age to purchase tobacco products is 18, however many people start younger than this

leading to approximately one in every five deaths [Figure 1) [Figure 1) [ FIGURE 1 Due to the large percentage of women utilizing nicotine products during pregnancy in the United States and globally, this review seeks to centralize the results of pre-clinical and clinical research focused on the neurobehavioral and neurodevelopmental complications associated with prenatal nicotine exposure (PNE)

For the stroke models, we created two bias covariates to account for possible differences between studies reporting subtype-specific effect size only and those reporting stroke as an aggregated outcome

Canrong W et al